FIGN

Across TCGA cell cohorts, FIGN mutation is significantly associated with the RNA expression of many other genes, with 647 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FIGN-associated genes across cancer lineages are TRMU, DNAJC16, and WRAP73. Each is linked with FIGN in more than 1 cancer types. Because this analysis shows association rather than direction, both FIGN-to-partner and partner-to-FIGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by FIGN-low versus FIGN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIGN→partner) and Y-score (partner→FIGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRMU →	+0.568	+2.043	.001	.008	3	2
LARGE_INTESTINE	DNAJC16 →	+0.658	+2.743	<.001	.001	3	2
LARGE_INTESTINE	WRAP73 →	+0.476	+3.850	.004	<.001	3	2
LARGE_INTESTINE	DENND10 →	+0.494	+2.043	.006	.008	3	2
LARGE_INTESTINE	SERAC1 →	+0.720	+3.652	<.001	<.001	3	2
LARGE_INTESTINE	ALKBH7 →	+0.473	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 647 associations by consensus.

TRMU by FIGN expression — LARGE_INTESTINE

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