FIG4

Across TCGA pan-cancer cohorts, FIG4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FIG4 data layer compared with 19 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FIG4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FIG4 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, LUAD, and CCRCC are the cancer types where FIG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.646	0.212	.001	19	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	10	view →
CCRCC	OS	Median	II,III,IV	0.647	0.867	.012	8	view →
LSCC	DFS	Median	III,IV	0.448	0.909	.020	5	view →
UCEC	DFS	Tertile	All	0.910	1.000	.037	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
HNSC	DFS	Median	All	0.840	0.702	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FIG4–GBM (OS)

Open the GBM breakdown →