FIG4

Across TCGA patient cohorts, FIG4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,678 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FIG4-associated genes across cancer lineages are BIN2, LIN9, and CDKN2AIPNL. Each is linked with FIG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both FIG4-to-partner and partner-to-FIG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FIG4 versus BIN2 in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIG4→partner) and Y-score (partner→FIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BIN2 →	+0.867	+0.144	.001	.008	3	4
LSCC	LIN9 →	-0.732	-0.181	<.001	<.001	3	4
UCEC	CDKN2AIPNL →	-0.507	-0.146	<.001	.005	3	4
BRCA	MRPL45 →	-0.631	-0.232	<.001	<.001	3	4
HNSC	DPH7 →	-0.484	-0.186	.002	<.001	3	4
HNSC	PMPCA →	-0.617	-0.238	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,678 associations by consensus.

FIG4 vs BIN2 — UCEC

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