FIG4

Across TCGA patient cohorts, FIG4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIG4-associated genes across cancer lineages are PCNA, FASN, and eIF4E. Each is linked with FIG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FIG4-to-partner and partner-to-FIG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FIG4-low versus FIG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIG4→partner) and Y-score (partner→FIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.174	+2.459	.020	.018	3	3
COAD	FASN →	+0.591	+2.815	.005	.036	3	2
UCEC	eIF4E →	+0.204	+3.598	.005	.001	3	2
UCEC	FoxM1 →	+0.199	+2.070	.026	.001	3	2
UCEC	p27_pT198 →	+0.075	+1.440	.043	.024	3	2
UCEC	TFRC →	+0.379	+1.874	.039	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PCNA by FIG4 expression — UCEC

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