FIG4

Across TCGA cell cohorts, FIG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,428 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible FIG4-associated GO terms across cancer lineages are 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process, Phosphatidylinositol-3-phosphate biosynthetic process, and Hair follicle placode formation. Each is linked with FIG4 in more than 19 cancer types. Because this analysis shows association rather than direction, both FIG4-to-partner and partner-to-FIG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process grouped by FIG4-low versus FIG4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FIG4→partner) and Y-score (partner→FIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.153	+1.064	<.001	<.001	3	20
LUNG_SCLC	Phosphatidylinositol-3-phosphate biosynthetic process →	+0.086	+0.983	.001	.001	3	15
BLOOD_Lymphoma	Hair follicle placode formation →	+0.080	+0.707	.001	<.001	3	13
LUNG_NSCLC_LUSC	Post-Golgi vesicle-mediated transport →	+0.076	+1.109	.007	.002	2	14
OVARY	7-methylguanosine mRNA capping →	+0.103	+0.777	.001	<.001	3	12
OVARY	7-methylguanosine RNA capping →	+0.103	+0.777	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,428 associations by consensus.

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process by FIG4 expression — SKIN

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