FIG4

Across TCGA cell cohorts, FIG4 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FIG4-associated genes across cancer lineages are FTMT, SMYD1, and C16orf92. Each is linked with FIG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIG4-to-partner and partner-to-FIG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by FIG4-low versus FIG4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIG4→partner) and Y-score (partner→FIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	SMYD1 →	+0.016	+5.357	<.001	.003	3	1
BLOOD_Leukemia	C16orf92 →	+0.259	+4.037	<.001	.004	3	1
BLOOD_Leukemia	OBP2B →	+0.045	+4.269	<.001	.002	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CCT8L2 →	+0.015	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

FTMT by FIG4 expression — SOFT_TISSUE

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