FIBIN

Across TCGA pan-cancer cohorts, FIBIN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FIBIN data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FIBIN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FIBIN expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where FIBIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.456	0.792	.006	18	view →
HNSC	DFS	Tertile	III,IV	0.597	0.925	.004	16	view →
PDAC	DFS	Tertile	All	0.651	0.913	.004	10	view →
OV	DFS	Tertile	All	1.000	0.576	.045	4	view →
UCEC	DFS	Tertile	III,IV	1.000	0.527	.049	4	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FIBIN–LSCC (DFS)

Open the LSCC breakdown →