FIBIN

Across TCGA patient cohorts, FIBIN mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FIBIN-associated genes across cancer lineages are ATM, eIF4E, and 4E-BP1. Each is linked with FIBIN in more than 2 cancer types. Because this analysis shows association rather than direction, both FIBIN-to-partner and partner-to-FIBIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FIBIN-low versus FIBIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIBIN→partner) and Y-score (partner→FIBIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.593	-3.986	<.001	<.001	3	3
UCEC	eIF4E →	+0.240	+3.820	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.472	+4.087	<.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.142	-2.188	.011	<.001	3	2
UCEC	PCNA →	+0.237	+2.169	.001	.003	3	2
UCEC	Caspase-8 →	-0.234	-2.201	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by FIBIN expression — UCEC

Explore this box plot interactively →