FIBIN

Across TCGA cell cohorts, FIBIN mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FIBIN-associated genes across cancer lineages are OR1E1, TRDN, and LRRC3C. Each is linked with FIBIN in more than 1 cancer types. Because this analysis shows association rather than direction, both FIBIN-to-partner and partner-to-FIBIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E1 grouped by FIBIN-low versus FIBIN-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIBIN→partner) and Y-score (partner→FIBIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR1E1 →	+0.504	+5.321	<.001	.005	3	1
LARGE_INTESTINE	TRDN →	+0.040	+4.054	<.001	.004	3	1
LARGE_INTESTINE	LRRC3C →	+0.395	+3.777	<.001	.007	3	1
BLOOD_Leukemia	OR4D9 →	+0.006	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR1E1 by FIBIN expression — CNS

Explore this box plot interactively →