FHOD3

Across TCGA patient cohorts, FHOD3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHOD3-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and PI3K-p110-a. Each is linked with FHOD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FHOD3-to-partner and partner-to-FHOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FHOD3-low versus FHOD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHOD3→partner) and Y-score (partner→FHOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.639	+2.247	<.001	.001	3	4
UCEC	FoxM1 →	+0.179	+1.688	.016	.013	3	3
UCEC	PI3K-p110-a →	-0.117	-1.807	.021	.003	3	3
STAD	Chk2 →	+0.405	+3.321	.005	.010	2	3
STAD	4E-BP1 →	+0.361	+3.000	.010	.034	2	3
UCEC	PDCD4 →	-0.413	-2.584	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by FHOD3 expression — UCEC

Explore this box plot interactively →