FHL5

Across TCGA cell cohorts, FHL5 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FHL5-associated genes across cancer lineages are ACER1, GSG1L2, and GUCA1A. Each is linked with FHL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHL5-to-partner and partner-to-FHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by FHL5-low versus FHL5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL5→partner) and Y-score (partner→FHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.093	+4.408	<.001	<.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GUCA1A →	+0.051	+2.841	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ACER1 by FHL5 expression — LARGE_INTESTINE

Explore this box plot interactively →