Across TCGA patient cohorts, FHL3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,537 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FHL3-associated genes across cancer lineages are AEBP1, COL5A1, and EMILIN1. Each is linked with FHL3 in more than 9 cancer types. Because this analysis shows association rather than direction, both FHL3-to-partner and partner-to-FHL3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL3→partner) and Y-score (partner→FHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AEBP1 →	+2.399	+0.975	<.001	<.001	3	10
OV	COL5A1 →	+2.248	+0.962	<.001	<.001	3	10
UCEC	EMILIN1 →	+1.788	+0.753	<.001	<.001	3	10
OV	COL8A1 →	+2.408	+0.965	<.001	<.001	3	10
OV	RASA3 →	+0.685	+0.571	<.001	<.001	3	10
OV	PDLIM7 →	+1.119	+0.779	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,537 associations by consensus.

Exploration

FHL3 survival (RNA) · tumor vs normal (RNA) · all FHL3 data types