Across TCGA patient cohorts, FHL3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHL3-associated genes across cancer lineages are PKC-a, EGFR_pY1068, and Caspase-8. Each is linked with FHL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHL3-to-partner and partner-to-FHL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL3→partner) and Y-score (partner→FHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-a →	+0.426	+3.013	.029	.018	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.459	.035	.020	3	1
UCEC	Caspase-8 →	-0.283	-3.143	.019	.018	3	1
UCEC	Chk2_pT68 →	-0.199	-3.312	.026	.010	3	1
UCEC	MEK1 →	+0.371	+3.321	.035	.010	2	1
UCEC	Cyclin-B1 →	+0.711	+3.584	.008	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

FHL3 survival (RNA) · tumor vs normal (RNA) · all FHL3 data types