FHL2

Across TCGA patient cohorts, FHL2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,008 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FHL2-associated genes across cancer lineages are SFRP4, MYL9, and SRPX2. Each is linked with FHL2 in more than 9 cancer types. Because this analysis shows association rather than direction, both FHL2-to-partner and partner-to-FHL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FHL2 versus SFRP4 in COAD, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL2→partner) and Y-score (partner→FHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SFRP4 →	+2.075	+0.355	<.001	<.001	3	10
UCEC	MYL9 →	+1.215	+0.806	<.001	<.001	3	9
BRCA	SRPX2 →	+0.984	+0.570	<.001	<.001	3	9
UCEC	ACTA2 →	+1.374	+0.571	<.001	<.001	3	9
LSCC	COL12A1 →	+1.527	+0.733	<.001	<.001	3	9
OV	ISLR →	+1.751	+0.754	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,008 associations by consensus.

FHL2 vs SFRP4 — COAD

Explore this scatter interactively →