FHL2

Across TCGA patient cohorts, FHL2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHL2-associated genes across cancer lineages are ASNS, 14-3-3_beta, and EGFR_pY1068. Each is linked with FHL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHL2-to-partner and partner-to-FHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FHL2-low versus FHL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL2→partner) and Y-score (partner→FHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.319	+2.000	.024	.030	3	2
UCEC	14-3-3_beta →	-0.105	-2.558	.008	.010	3	1
UCEC	EGFR_pY1068 →	-0.253	-2.000	.010	.010	3	1
UCEC	eIF4G →	+0.265	+2.459	.029	.018	3	1
UCEC	A-Raf_pS299 →	-0.161	-2.459	<.001	.019	3	1
UCEC	INPP4B →	-0.272	-2.321	.032	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ASNS by FHL2 expression — UCEC

Explore this box plot interactively →