FHL2

Across TCGA cell cohorts, FHL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,616 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FHL2-associated GO terms across cancer lineages are Atrial cardiac muscle cell differentiation, Atrial cardiac muscle cell development, and Ventricular cardiac muscle cell development. Each is linked with FHL2 in more than 18 cancer types. Because this analysis shows association rather than direction, both FHL2-to-partner and partner-to-FHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Atrial cardiac muscle cell differentiation grouped by FHL2-low versus FHL2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL2→partner) and Y-score (partner→FHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Atrial cardiac muscle cell differentiation →	+1.802	+3.469	<.001	<.001	3	19
BLOOD_Leukemia	Atrial cardiac muscle cell development →	+1.802	+3.469	<.001	<.001	3	19
LIVER	Ventricular cardiac muscle cell development →	+0.400	+3.662	.001	<.001	3	14
BONE	Regulation of cell-substrate adhesion →	+0.137	+3.730	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Regulation of hemostasis →	+0.223	+3.514	.002	.003	3	13
BONE	Regulation of cell-matrix adhesion →	+0.159	+3.827	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,616 associations by consensus.

Atrial cardiac muscle cell differentiation by FHL2 expression — BLOOD_Leukemia

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