FHL1

Across TCGA pan-cancer cohorts, FHL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FHL1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FHL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FHL1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where FHL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.632	0.316	.004	41	view →
CCRCC	OS	Median	All	0.768	0.924	.016	20	view →
LUAD	DFS	Tertile	III,IV	0.269	0.853	.001	15	view →
UCEC	OS	Quartile	II,III,IV	0.503	1.000	.043	4	view →
LSCC	DFS	Quartile	II,III,IV	0.784	1.000	.032	1	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FHL1–PDAC (OS)

Open the PDAC breakdown →