FHL1

Across TCGA patient cohorts, FHL1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHL1-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and p62 Lck ligand. Each is linked with FHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHL1-to-partner and partner-to-FHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FHL1-low versus FHL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL1→partner) and Y-score (partner→FHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.137	+1.137	.001	.041	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.401	-1.999	.004	.002	3	2
UCEC	p62 Lck ligand →	+0.394	+4.169	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.076	-1.780	.016	.024	3	1
UCEC	eIF4E →	+0.193	+2.736	.003	<.001	3	1
UCEC	A-Raf_pS299 →	-0.128	-1.925	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Notch1 by FHL1 expression — UCEC

Explore this box plot interactively →