FHL1

Across TCGA cell cohorts, FHL1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FHL1-associated genes across cancer lineages are STRA8, USP29, and RNASE9. Each is linked with FHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHL1-to-partner and partner-to-FHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STRA8 grouped by FHL1-low versus FHL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL1→partner) and Y-score (partner→FHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	STRA8 →	+0.024	+4.754	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.016	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP10-3 →	+0.032	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	GAGE12D →	+2.651	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MBD3L2 →	+0.151	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

STRA8 by FHL1 expression — CNS

Explore this box plot interactively →