Across TCGA patient cohorts, FHIT RNA expression is significantly associated with the protein abundance of many other proteins, with 12,386 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FHIT-associated proteins across cancer lineages are DDAH1, BBS7, and FRY. Each is linked with FHIT in more than 5 cancer types. Because this analysis shows association rather than direction, both FHIT-to-partner and partner-to-FHIT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FHIT→partner) and Y-score (partner→FHIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDAH1 →	+0.585	+0.530	<.001	<.001	3	6
LSCC	BBS7 →	+0.291	+0.375	<.001	<.001	3	5
HNSC	FRY →	+0.433	+0.655	.001	<.001	3	5
BRCA	APPL1 →	+0.237	+0.669	.003	<.001	3	4
HNSC	ACAA2 →	+0.339	+0.574	<.001	<.001	3	4
BRCA	NCS1 →	-0.472	-0.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,386 associations by consensus.

Exploration

FHIT survival (RNA) · tumor vs normal (RNA) · all FHIT data types