Across TCGA patient cohorts, FHIT protein abundance is significantly associated with the RNA expression of many other genes, with 16,669 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FHIT-associated genes across cancer lineages are NCAPH, TUBA1C, and PPIAP71. Each is linked with FHIT in more than 6 cancer types. Because this analysis shows association rather than direction, both FHIT-to-partner and partner-to-FHIT results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHIT→partner) and Y-score (partner→FHIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NCAPH →	-0.869	-0.394	<.001	.006	3	7
OV	TUBA1C →	-0.763	-0.567	<.001	<.001	3	7
UCEC	PPIAP71 →	+1.117	+0.589	<.001	<.001	3	7
UCEC	PRR11 →	-1.041	-0.459	<.001	<.001	3	7
OV	CDKN3 →	-0.963	-0.459	<.001	<.001	3	6
LSCC	CENPI →	-0.874	-0.505	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,669 associations by consensus.

Exploration

FHIT survival (RNA) · tumor vs normal (RNA) · all FHIT data types