Across TCGA cell cohorts, FHIT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,475 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible FHIT-associated GO terms across cancer lineages are Branched-chain amino acid metabolic process, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, and Mitotic spindle midzone assembly. Each is linked with FHIT in more than 7 cancer types. Because this analysis shows association rather than direction, both FHIT-to-partner and partner-to-FHIT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FHIT→partner) and Y-score (partner→FHIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Branched-chain amino acid metabolic process →	+0.105	+0.889	<.001	.001	3	8
PANCREAS	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.080	+0.925	.001	.004	2	8
KIDNEY	Mitotic spindle midzone assembly →	-0.257	-1.035	<.001	.007	3	7
OVARY	Positive regulation of dopamine receptor signaling pathway →	-0.144	-1.197	<.001	<.001	3	7
CNS	Amino acid metabolic process →	+0.039	+0.942	<.001	<.001	3	7
BREAST	Purine nucleoside transmembrane transport →	+0.120	+0.808	.004	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,475 associations by consensus.

Exploration

FHIT survival (RNA) · tumor vs normal (RNA) · all FHIT data types