FHDC1

Across TCGA patient cohorts, FHDC1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHDC1-associated genes across cancer lineages are eIF4E, Ku80, and Caspase-7-cleavedD198. Each is linked with FHDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FHDC1-to-partner and partner-to-FHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FHDC1-low versus FHDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHDC1→partner) and Y-score (partner→FHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+4.169	.006	<.001	3	3
UCEC	Ku80 →	+0.250	+1.906	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.775	+1.604	<.001	.005	3	3
LUSC	Fibronectin →	-0.517	-2.990	.038	.036	3	2
SKCM	IGFBP2 →	-0.394	-1.700	.044	.040	3	2
SKCM	DJ-1 →	+0.172	+1.339	.012	.044	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eIF4E by FHDC1 expression — UCEC

Explore this box plot interactively →