FHDC1

Across TCGA cell cohorts, FHDC1 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FHDC1-associated genes across cancer lineages are ST8SIA3, SSMEM1, and TPD52L3. Each is linked with FHDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FHDC1-to-partner and partner-to-FHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ST8SIA3 grouped by FHDC1-low versus FHDC1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHDC1→partner) and Y-score (partner→FHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ST8SIA3 →	+0.053	+4.807	<.001	.006	3	2
LARGE_INTESTINE	SSMEM1 →	+0.019	+2.444	.005	.008	3	1
LARGE_INTESTINE	TPD52L3 →	+0.025	+2.777	.006	.004	3	1
LARGE_INTESTINE	RIPPLY2 →	+0.336	+2.518	<.001	.006	3	1
LARGE_INTESTINE	TMEM233 →	+0.217	+2.518	.004	.006	3	1
LARGE_INTESTINE	KCNN2 →	+0.754	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

ST8SIA3 by FHDC1 expression — BLOOD_Myeloma

Explore this box plot interactively →