FGR

Across TCGA patient cohorts, FGR mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGR-associated genes across cancer lineages are mTOR_pS2448, p38-MAPK_pT180_Y182, and PCNA. Each is linked with FGR in more than 1 cancer types. Because this analysis shows association rather than direction, both FGR-to-partner and partner-to-FGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by FGR-low versus FGR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGR→partner) and Y-score (partner→FGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	mTOR_pS2448 →	-0.202	-3.000	.032	.035	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.498	-2.807	.003	.003	3	2
UCEC	PCNA →	+0.189	+2.169	.019	.003	3	2
UCEC	ATM →	-0.454	-3.308	.007	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.760	+2.926	<.001	<.001	3	2
SKCM	Akt →	-0.404	-3.169	.011	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by FGR expression — SKCM

Explore this box plot interactively →