FGR

Across TCGA cell cohorts, FGR mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FGR-associated genes across cancer lineages are CRYGC, H2BW2, and MYL7. Each is linked with FGR in more than 1 cancer types. Because this analysis shows association rather than direction, both FGR-to-partner and partner-to-FGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYGC grouped by FGR-low versus FGR-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGR→partner) and Y-score (partner→FGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CRYGC →	+0.053	+5.643	<.001	.002	3	1
SKIN	H2BW2 →	+0.092	+4.467	<.001	.004	3	1
SKIN	MYL7 →	+0.465	+4.930	<.001	.001	3	1
SKIN	RIT2 →	+0.030	+5.022	<.001	.002	3	1
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
SKIN	TNMD →	+0.168	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

CRYGC by FGR expression — LUNG_SCLC

Explore this box plot interactively →