FGL2

Across TCGA pan-cancer cohorts, FGL2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FGL2 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FGL2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGL2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where FGL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.871	1.000	.011	90	view →
HNSC	DFS	Median	II,III,IV	0.515	0.801	<.001	41	view →
PDAC	DFS	Quartile	All	0.483	0.245	.002	26	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	3	view →
LSCC	DFS	Quartile	All	1.000	0.507	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FGL2–COAD (DFS)

Open the COAD breakdown →