FGL2

Across TCGA patient cohorts, FGL2 mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGL2-associated genes across cancer lineages are RN7SL383P, RPL32P8, and HTR3D. Each is linked with FGL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGL2-to-partner and partner-to-FGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL383P grouped by FGL2-low versus FGL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGL2→partner) and Y-score (partner→FGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL383P →	+0.039	+3.810	<.001	.008	3	3
BLCA	RPL32P8 →	+0.223	+5.266	<.001	.001	3	2
SKCM	HTR3D →	+0.018	+2.011	.008	.003	3	2
SKCM	SLC35F6 →	+0.473	+2.328	.003	.003	3	2
SKCM	RNU6-855P →	+0.069	+3.810	<.001	.008	3	2
UCEC	RN7SKP286 →	+0.058	+4.475	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

RN7SL383P by FGL2 expression — SKCM

Explore this box plot interactively →