FGL2

Across TCGA patient cohorts, FGL2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGL2-associated genes across cancer lineages are Src, c-Met_pY1235, and Bim. Each is linked with FGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGL2-to-partner and partner-to-FGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by FGL2-low versus FGL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGL2→partner) and Y-score (partner→FGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src →	-0.259	-2.321	.012	.035	3	2
UCEC	c-Met_pY1235 →	+0.102	+2.321	.006	.035	3	2
SKCM	Bim →	-0.398	-2.321	.002	.035	3	1
UCEC	Ku80 →	+0.244	+2.335	.040	.020	3	1
UCEC	VHL →	-1.263	-3.459	<.001	.005	3	1
UCEC	4E-BP1_pT37_T46 →	-0.494	-2.321	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Src by FGL2 expression — UCEC

Explore this box plot interactively →