FGL2

Across TCGA cell cohorts, FGL2 mutation is significantly associated with the mutation status of many other genes, with 835 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FGL2-associated genes across cancer lineages are SLC5A1, UGGT2, and RELB. Each is linked with FGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGL2-to-partner and partner-to-FGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A1 grouped by FGL2-low versus FGL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGL2→partner) and Y-score (partner→FGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A1 →	+4.560	+4.870	<.001	<.001	1	2
BLOOD_Leukemia	UGGT2 →	+3.338	+4.083	.003	.003	1	2
BLOOD_Leukemia	RELB →	+2.823	+3.665	.008	.008	1	2
BLOOD_Leukemia	GPI →	+3.560	+4.247	.002	.002	1	2
BLOOD_Leukemia	PIK3R2 →	+4.238	+5.662	<.001	<.001	1	2
BLOOD_Leukemia	PBX4 →	+4.560	+4.309	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 835 associations by consensus.

SLC5A1 by FGL2 expression — BLOOD_Leukemia

Explore this box plot interactively →