FGL1

Across TCGA patient cohorts, FGL1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGL1-associated genes across cancer lineages are eIF4G, ACVRL1, and Ku80. Each is linked with FGL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGL1-to-partner and partner-to-FGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by FGL1-low versus FGL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGL1→partner) and Y-score (partner→FGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.347	+2.584	.016	.011	3	1
UCEC	ACVRL1 →	-0.168	-2.302	.008	.034	3	1
UCEC	Ku80 →	+0.319	+3.013	.003	.018	3	1
UCEC	Mre11 →	-0.127	-2.973	.001	.035	3	1
UCEC	P-Cadherin →	-0.183	-3.687	.006	.001	3	1
UCEC	Annexin-1 →	+0.621	+2.827	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4G by FGL1 expression — UCEC

Explore this box plot interactively →