FGGY

Across TCGA pan-cancer cohorts, FGGY mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FGGY data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FGGY mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FGGY expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where FGGY mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	23	view →
HNSC	DFS	Tertile	IV	0.919	0.613	.012	16	view →
UCEC	DFS	Tertile	All	1.000	0.887	.036	8	view →
PDAC	OS	Median	IV	0.491	0.836	.024	6	view →
LSCC	DFS	Quartile	All	0.866	0.955	.041	3	view →
GBM	DFS	Quartile	All	0.522	0.232	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FGGY–CCRCC (DFS)

Open the CCRCC breakdown →