FGGY

Across TCGA patient cohorts, FGGY mutation is significantly associated with the RNA expression of many other genes, with 2,298 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGGY-associated genes across cancer lineages are MIR6864, ATP5MC3, and ZNF18. Each is linked with FGGY in more than 2 cancer types. Because this analysis shows association rather than direction, both FGGY-to-partner and partner-to-FGGY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6864 grouped by FGGY-low versus FGGY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGGY→partner) and Y-score (partner→FGGY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6864 →	+0.513	+1.739	<.001	.001	3	2
UCEC	ATP5MC3 →	+0.384	+3.459	.008	.005	3	2
UCEC	ZNF18 →	+0.319	+1.906	.005	.001	3	2
UCEC	SLC25A28 →	+0.257	+2.839	.005	.001	3	2
UCEC	ATP5MPL →	+0.439	+2.627	<.001	<.001	3	2
UCEC	DHRS4 →	+0.422	+4.003	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,298 associations by consensus.

MIR6864 by FGGY expression — UCEC

Explore this box plot interactively →