FGGY

Across TCGA cell cohorts, FGGY mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGGY-associated genes across cancer lineages are XKR4, SLC22A6, and AGTR2. Each is linked with FGGY in more than 1 cancer types. Because this analysis shows association rather than direction, both FGGY-to-partner and partner-to-FGGY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XKR4 grouped by FGGY-low versus FGGY-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGGY→partner) and Y-score (partner→FGGY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	XKR4 →	+0.021	+4.017	<.001	.007	3	1
BLOOD_Myeloma	SLC22A6 →	+0.036	+4.807	<.001	.006	3	1
KIDNEY	AGTR2 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	GDF3 →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GAGE2A →	+0.883	+5.000	<.001	.005	3	1
KIDNEY	LORICRIN →	+0.013	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

XKR4 by FGGY expression — OESOPHAGUS

Explore this box plot interactively →