FGG

Across TCGA pan-cancer cohorts, FGG mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FGG data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FGG mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FGG expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

CCRCC, GBM, and LUAD are the cancer types where FGG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.498	0.856	.006	35	view →
GBM	OS	Median	All	0.381	0.698	<.001	28	view →
LUAD	OS	Quartile	II,III,IV	0.208	0.758	.003	17	view →
LSCC	DFS	Median	II,III,IV	0.834	1.000	.005	16	view →
UCEC	OS	Median	All	0.906	1.000	.009	14	view →
HNSC	DFS	Median	All	0.532	0.737	.008	13	view →
OV	DFS	Median	All	0.900	0.672	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FGG–CCRCC (OS)

Open the CCRCC breakdown →