FGG

Across TCGA patient cohorts, FGG mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGG-associated genes across cancer lineages are C-Raf, INPP4B, and PDCD4. Each is linked with FGG in more than 1 cancer types. Because this analysis shows association rather than direction, both FGG-to-partner and partner-to-FGG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FGG-low versus FGG-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGG→partner) and Y-score (partner→FGG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.182	+2.330	.005	.020	3	2
UCEC	INPP4B →	-0.224	-1.584	.033	.032	3	2
UCEC	PDCD4 →	-0.520	-1.459	<.001	.012	3	2
UCEC	Rad50 →	-0.229	-1.459	.003	.012	3	2
UCEC	ASNS →	+0.308	+1.415	.008	.043	3	2
UCEC	ATM →	-0.588	-1.716	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

C-Raf by FGG expression — COAD

Explore this box plot interactively →