FGG

Across TCGA cell cohorts, FGG mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible FGG-associated genes across cancer lineages are PRAMEF27, P2RY13, and CD300H. Each is linked with FGG in more than 1 cancer types. Because this analysis shows association rather than direction, both FGG-to-partner and partner-to-FGG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF27 grouped by FGG-low versus FGG-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGG→partner) and Y-score (partner→FGG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRAMEF27 →	+0.013	+5.087	<.001	.004	3	1
SKIN	P2RY13 →	+0.005	+3.684	<.001	.006	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
BREAST	VCY1B →	+1.590	+4.421	<.001	.004	3	1
BREAST	TXNDC8 →	+0.005	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRAMEF27 by FGG expression — URINARY_TRACT

Explore this box plot interactively →