FGFRL1

Across TCGA cell cohorts, FGFRL1 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FGFRL1-associated genes across cancer lineages are PRRG3, CCDC197, and TMEM235. Each is linked with FGFRL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGFRL1-to-partner and partner-to-FGFRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRRG3 grouped by FGFRL1-low versus FGFRL1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFRL1→partner) and Y-score (partner→FGFRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRRG3 →	+0.082	+4.129	<.001	.007	3	1
STOMACH	CCDC197 →	+0.033	+4.129	<.001	.007	3	1
STOMACH	TMEM235 →	+0.012	+4.794	<.001	.001	3	1
STOMACH	KRTAP10-7 →	+0.020	+4.285	<.001	.007	3	1
BLOOD_Leukemia	FBN3 →	+0.176	+3.454	<.001	.007	3	1
BLOOD_Leukemia	NPFFR1 →	+0.009	+2.774	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PRRG3 by FGFRL1 expression — STOMACH

Explore this box plot interactively →