FGFR2

Across TCGA patient cohorts, FGFR2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGFR2-associated genes across cancer lineages are Caspase-7-cleavedD198, PREX1, and FOXO3a_pS318_S321. Each is linked with FGFR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGFR2-to-partner and partner-to-FGFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FGFR2-low versus FGFR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR2→partner) and Y-score (partner→FGFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.467	+1.363	<.001	.001	3	3
SKCM	PREX1 →	-0.363	-2.304	.001	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.072	-1.312	.011	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.109	-0.889	.004	.010	3	2
UCEC	JNK2 →	+0.108	+0.961	.017	.022	3	2
UCEC	Ku80 →	+0.130	+0.820	.016	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by FGFR2 expression — UCEC

Explore this box plot interactively →