FGFR2

Across TCGA cell cohorts, FGFR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,401 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FGFR2-associated GO terms across cancer lineages are Branching morphogenesis of a nerve, Glandular epithelial cell differentiation, and Morphogenesis of an epithelial fold. Each is linked with FGFR2 in more than 18 cancer types. Because this analysis shows association rather than direction, both FGFR2-to-partner and partner-to-FGFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Branching morphogenesis of a nerve grouped by FGFR2-low versus FGFR2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR2→partner) and Y-score (partner→FGFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Branching morphogenesis of a nerve →	+2.075	+3.675	<.001	<.001	3	19
LIVER	Glandular epithelial cell differentiation →	+1.786	+2.637	<.001	.006	3	17
LUNG_NSCLC_LUSC	Morphogenesis of an epithelial fold →	+1.944	+3.557	<.001	<.001	3	17
LIVER	Epithelial cell differentiation involved in prostate gland development →	-0.340	-3.571	<.001	<.001	3	17
LUNG_SCLC	Lacrimal gland development →	+1.120	+2.151	<.001	.003	3	16
BREAST	Forebrain ventricular zone progenitor cell division →	+1.407	+2.976	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

Branching morphogenesis of a nerve by FGFR2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →