FGFR1

Across TCGA pan-cancer cohorts, FGFR1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FGFR1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FGFR1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGFR1 expression acts as an unfavorable survival marker, although some lineages such as STAD and MESO show a favorable association.

LUAD, UCEC, and SKCM are the cancer types where FGFR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	IV	0.342	0.893	<.001	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	II,III,IV	0.223	0.735	<.001	6	view →
STAD	DFS	Median	III,IV	1.000	0.311	.038	5	view →
MESO	DFS	Median	All	1.000	0.179	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FGFR1–LUAD (DFS)

Open the LUAD breakdown →