FGFR1

Across TCGA pan-cancer cohorts, FGFR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FGFR1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FGFR1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FGFR1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

GBM, LUAD, and UCEC are the cancer types where FGFR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.199	0.588	<.001	32	view →
LUAD	DFS	Tertile	All	0.886	0.416	.004	16	view →
UCEC	OS	Quartile	All	0.861	1.000	.022	10	view →
HNSC	DFS	Median	III,IV	0.222	0.761	.038	6	view →
LSCC	OS	Median	III,IV	0.888	0.569	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FGFR1–GBM (OS)

Open the GBM breakdown →