FGFR1

Across TCGA pan-cancer cohorts, FGFR1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FGFR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FGFR1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FGFR1 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and PDAC are the cancer types where FGFR1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGFR1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.435	.001	11	view →
LSCC	Female	All	−0.455	<.001	8	view →
PDAC	All	All	−0.393	.002	4	view →
LUAD	All	All	−0.262	<.001	3	view →
OV	All	All	−0.848	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FGFR1–HNSC

Open the HNSC breakdown →