FGFR1

Across TCGA patient cohorts, FGFR1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGFR1-associated genes across cancer lineages are Cyclin-B1, TIGAR, and ASNS. Each is linked with FGFR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGFR1-to-partner and partner-to-FGFR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FGFR1-low versus FGFR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR1→partner) and Y-score (partner→FGFR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.893	+2.820	<.001	.035	3	3
COAD	TIGAR →	+0.555	+2.178	.002	.035	3	3
UCEC	ASNS →	+0.396	+1.584	.001	.034	3	3
UCEC	ATM →	-0.580	-2.000	<.001	.003	3	3
COAD	MIG-6 →	+0.107	+2.229	.021	.032	3	2
COAD	Caspase-7-cleavedD198 →	+0.994	+3.330	.007	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Cyclin-B1 by FGFR1 expression — SKCM

Explore this box plot interactively →