FGFR1

Across TCGA cell cohorts, FGFR1 mutation is significantly associated with the RNA expression of many other genes, with 745 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGFR1-associated genes across cancer lineages are ANKRD54, EIF3L, and CCDC134. Each is linked with FGFR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGFR1-to-partner and partner-to-FGFR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD54 grouped by FGFR1-low versus FGFR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR1→partner) and Y-score (partner→FGFR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD54 →	+0.448	+2.588	.005	.004	3	1
LARGE_INTESTINE	EIF3L →	+0.481	+3.237	.004	.003	3	1
LARGE_INTESTINE	CCDC134 →	+0.649	+2.502	.005	.005	3	1
LARGE_INTESTINE	SLC25A17 →	+0.595	+2.502	.002	.005	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.639	+3.628	<.001	<.001	3	1
LARGE_INTESTINE	PHF5A →	+0.548	+2.502	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 745 associations by consensus.

ANKRD54 by FGFR1 expression — LARGE_INTESTINE

Explore this box plot interactively →