FGFBP3

Across TCGA pan-cancer cohorts, FGFBP3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FGFBP3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FGFBP3 RNA is repressed in tumor relative to normal tissue. In most cancer types FGFBP3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where FGFBP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGFBP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.880	<.001	11	view →
KIRC	Male	II,III,IV	−0.625	<.001	11	view →
KICH	Male	All	−1.181	<.001	9	view →
KIRP	All	All	−0.687	<.001	7	view →
LIHC	Female	II,III,IV	+0.551	<.001	7	view →
BRCA	Female	II,III,IV	−0.588	<.001	6	view →
COAD	All	All	+0.392	.001	6	view →
CHOL	All	All	+0.542	.002	5	view →
STAD	Male	All	+0.363	.006	3	view →
LUAD	Female	All	−0.235	.025	3	view →
LUAD	All	IV	+0.890	.029	2	view →
PAAD	Female	All	−0.599	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FGFBP3–THCA

Open the THCA breakdown →