FGF8

Across TCGA pan-cancer cohorts, FGF8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FGF8 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FGF8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FGF8 expression acts as an unfavorable survival marker.

HNSC, OV, and READ are the cancer types where FGF8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.143	0.752	<.001	66	view →
OV	OS	Median	II,III,IV	0.022	0.844	<.001	48	view →
READ	OS	Median	III,IV	0.111	0.903	<.001	31	view →
SKCM	OS	Median	All	0.249	0.781	.011	14	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FGF8–HNSC (OS)

Open the HNSC breakdown →