FGF4

Across TCGA pan-cancer cohorts, FGF4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FGF4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FGF4 RNA is repressed in tumor relative to normal tissue. In most cancer types FGF4 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, STAD, and READ are the cancer types where FGF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.027	<.001	6	view →
STAD	All	All	+0.055	.002	5	view →
READ	Male	All	+0.156	.002	4	view →
THCA	All	All	+0.053	.002	3	view →
KICH	Male	All	−0.027	.021	3	view →
UCEC	All	All	+0.649	.048	2	view →
COAD	All	II,III,IV	+0.062	.021	2	view →
BLCA	Female	All	+0.018	.023	2	view →
LUAD	All	II,III,IV	+0.013	.031	2	view →
LIHC	Male	All	+0.010	.017	2	view →
STAD	Male	IV	−0.025	.037	1	view →
KIRP	Male	III,IV	−0.025	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

FGF4–KIRC

Open the KIRC breakdown →