FGF23

Across TCGA patient cohorts, FGF23 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,724 significant associations in total. STAD shows the largest number of these associations.

The most reproducible FGF23-associated GO terms across cancer lineages are Regulation of protein serine/threonine kinase activity, Positive regulation of protein catabolic process, and Ribosome assembly. Each is linked with FGF23 in more than 16 cancer types. Because this analysis shows association rather than direction, both FGF23-to-partner and partner-to-FGF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein serine/threonine kinase activity grouped by FGF23-low versus FGF23-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF23→partner) and Y-score (partner→FGF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of protein serine/threonine kinase activity →	+0.049	+0.193	<.001	<.001	3	17
STAD	Positive regulation of protein catabolic process →	+0.048	+0.206	<.001	<.001	3	17
STAD	Ribosome assembly →	+0.065	+0.318	<.001	<.001	3	17
ESCA	Regulation of signal transduction by p53 class mediator →	+0.082	+0.245	.001	.001	3	16
ESCA	Protein stabilization →	+0.066	+0.301	.001	.001	3	15
STAD	Positive regulation of DNA metabolic process →	+0.050	+0.249	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,724 associations by consensus.

Regulation of protein serine/threonine kinase activity by FGF23 expression — ESCA

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