FGF23

Across TCGA patient cohorts, FGF23 mutation is significantly associated with the RNA expression of many other genes, with 1,246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF23-associated genes across cancer lineages are NELFB, SSMEM1, and ASB6. Each is linked with FGF23 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGF23-to-partner and partner-to-FGF23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NELFB grouped by FGF23-low versus FGF23-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF23→partner) and Y-score (partner→FGF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NELFB →	+0.340	+1.879	.005	.004	3	3
BRCA	SSMEM1 →	+0.112	+3.630	<.001	.008	3	3
LUAD	ASB6 →	+0.503	+3.416	<.001	.004	3	3
LUAD	ARRDC1-AS1 →	+0.572	+3.357	<.001	.005	3	3
UCEC	ARPC5L →	+0.392	+2.364	.002	.003	3	3
UCEC	MED27 →	+0.368	+2.386	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,246 associations by consensus.

NELFB by FGF23 expression — SKCM

Explore this box plot interactively →